The Grim Favor system is another reliable way to obtain Horadric Vials. Completing ten Grim Favors allows you to redeem a reward cache from the Tree of Diablo IV gold Whispers. These caches often include Horadric Vials among other upgrade materials, gold, and gear. It's a great option for players at all levels, and especially helpful between major world events like Helltides.

Try “Helpout” Activities
For players in the early game or those looking for low-effort tasks, Helpout quests provide an easy route to farming Horadric Vials. These missions can be completed at any level and often reward a handful of vials, making them great for casual players or those just starting out in a new season.

Run Nightmare Dungeons and Horadric Vaults
As you climb to higher world tiers, Nightmare Dungeons and Horadric Vaults become your main sources of Horadric Vials. These dungeons are packed with elite enemies, chests, and minibosses—all of which have a cheap Diablo 4 Items higher chance to drop vials. Horadric Vaults are especially valuable thanks to their high-density layouts and high-rarity loot drops.