Tadalista should never be used with nitrate medications such as nitroglycerin, as this can cause a dangerous fall in blood pressure. Caution is also required in individuals with heart disease, liver or kidney disorders, or those taking blood pressure–lowering medicines. During sexual arousal, the body releases nitric oxide, which helps relax smooth muscles in the penile blood vessels. Tadalafil enhances this natural process by blocking the PDE5 enzyme, allowing increased blood flow and improved erectile response. https://www.genericday.com/tadalista.html